Jiss Maria Louis
Rajiv Gandhi Center for Biotechnology, India
Title: TGF-β regulates recurrence by inducing self-renewal ability in cancer cells
Biography
Biography: Jiss Maria Louis
Abstract
Recurrence after chemotherapy often hampers the treatment outcome of oral cancer which is believed to be due to the selection of cancer stem cells that recreate tumor after the withdrawal of the drug. Emerging evidences suggest the involvement of a tumor niche in recurrence by inducing CSC properties like self-renewal ability in cancer cells escaping chemotherapy. Here, we used model systems using tumor cells and growth–arrested fibroblasts, isolated from OSCC samples to generate short-term co-culture, long term 3D-co-culture on alginate matrix and xeongrafts. Our results show that TGF-β secreted by stromal elements of tumor niche is regulating recurrence by inducing self-renewal property. We also show that this induction is independent of Smad4-mediated canonical pathway. It is mediated by another transcription factor, TIF1γ which was identified as a regulator of hematopoesis. Collectively, our results show that recurrence is regulated by tumor niche-mediated, TGF-β-induced self-renewal that depends on TIF1γ.