Tessy Thomas Maliekal
Rajiv Gandhi Centre for Biotechnology, India
Title: TIF1γ is a central player in the regulation of self-renewal ability in cancer cells
Biography
Biography: Tessy Thomas Maliekal
Abstract
Recurrence is a major reason for mortality in many forms of cancer including oral squamous cell carcinoma (OSCC). It is explained as a continuing process in which cancer cells possessing self-renewal ability and resistance to therapy survive the treatment and recreate tumor after the withdrawal of the treatment. Our results show that tumor micro environment induce self-renewal property in cells surviving chemotherapy which enhances recurrence. We identified a transcription factor, TIF1γ which was previously known as a regulator of hematopoiesis as a regulator of self-renewal ability. We show that this molecule is indispensible for the induction of self-renewal by important pathways regulating cancer stem cells. Further we identified intermediate molecules regulating the function of TIF1γ using proteomic analysis. The role of TIF1γ in self-renewal ability and the various down-stream molecules and pathways regulating the function of this molecule will be discussed.